RESEARCH ARTICLE A comparison of CKD-EPI filtration rate and measure c

Accurate assessment of renal function is a priority in the management of critically ill patients. Clinicians regularly utilize such information to help guide drug dosing, optimize fluid, acid–base, and electrolyte management, tailor nutritional requirements, and assess the need for renal replacement therapy (RRT). Rising plasma creatinine (CR) concentrations often trigger clinical interventions, in-cluding dose reduction of renally eliminated agents. In contrast, plasma CR concentrations within the reported reference range appear to be less useful. Normal values in the critically ill have been associated with both augmented creatinine clearance (CLCR) [1], and occult acute kidney injury (AKI) [2]. Driven primarily by a desire to more effectively monitor and screen for chronic kidney disease (CKD), formulae using simple demographic variables have been developed to estimate the glomerular filtration rate (eGFR). The most commonly applied include the Modification of Diet i