© 2012 Hellenic Society of Gastroenterology www.annalsgastro.gr Current management of functional dyspepsia: impact of Rome III subdivision

Abstract Functional dyspepsia (FD) is a highly prevalent disease characterized by symptoms originat-ing from the gastroduodenal region in the absence of underlying organic disease. The Rome III consensus made a distinction between meal-induced and meal-unrelated symptoms and proposed subdivision of FD into postprandial distress syndrome and epigastric pain syn-drome. The applicability of this subdivision and the impact on management are areas of active research. So far, empirical approaches are still employed for the treatment of FD, although various therapeutic modalities for FD have been explored; acid-suppressive, prokinetic, and fundic relaxant drugs, antidepressants and psychological therapies. FD remains a challenge and presents unmet clinical needs