RESEARCH An inverse m properties of

the pigmented iris epithelium rubs against the lens resulting in pigment liberation, occlusion of the trabecular meshwork [2] and elevated IOP. Therefore, understanding theBackground Glaucoma is the major cause of irreversible blindness worldwide. Most forms of glau-coma are associated with elevated intraocular pressure(IOP), some forms could lead to abnormalities of the iris morphology. In primary angle closure glaucoma, the iris bows anteriorly, aqueous humor outflow is impeded in moving through the pupil, resulting in Background: Understanding the mechanical properties of the iris can help to have an insight into the eye diseases with abnormalities of the iris morphology. Material parameters of the iris were simply calculated relying on the ex vivo experiment. However, the mechanical response of the iris in vivo is different from that ex vivo, therefore, a method was put forward to determine the material parameters of the iris using the optimization method in combination with the finite element method based on the in vivo experiment. Material and methods: Ocular hypertension was induced by rapid perfusion to th