©2014 by Anais Brasileiros de Dermatologia

Thirty-one year old, white female presented multiple round, brilliant, asymptomatic nor-mochromic, hyperkeratotic papules, measuring approximately 1-2 mm in diameter, on the transition area between the ventral and dorsal surfaces of the hands (Figure 1). She reported the appearance of lesions during adolescence, not associated with trau-ma, and with progressive increase in number. She cited similar cases in her family (cousin and sister). An excisional biopsy was performed for diagnostic con-firmation on a papule on the right hand. Histological exam, stained with hematoxylin eosin showed marked compact hyperorthokeratosis, over an inden-tation of the epidermal border, which appeared thick-ened (Figure 2). Verhoeff staining (for elastic fibers) did not show any alterations on the dermis fiber struc-ture (Figure 3). DOI