ORIGINAL ARTICLE Curcumin nanoparticles: physico-chemical fabrication and its in vitro efficacy against human pathogens

Abstract Curcumin is one of the polyphenols, which has been known for its medicinal use since long time. Cur-cumin shows poor solubility and low absorption, and therefore, its use as nanoparticles is beneficial due to their greater solubility and absorption. The main aim of the present study was the formation of curcumin nanoparticles (Nano curcu), evaluation of their antibacterial activity against human pathogenic bacteria and formulation of Nano curcu-based cream. We synthesized Nano curcu by sonication method. The synthesis of Nano curcu was assessed for their solubility in water and by UV–visible spectrophotometry. Further, the nanoparticles were char-acterized by Fourier transform infrared spectroscopy, transmission electron microscopy, nanoparticle tracking and analysis, and zeta potential analysis. In vitro antibac-terial activity of Nano curcu was evaluated against Escherichia coli, Staphylococcus aureus, and Pseu-domonas aeruginosa. The cream containing Nano curcu was found to be effective against human bacterial patho-gens and hence can be used for treatment of bacterial diseases