Add to ORKGAn increasing number of investigations including human studies demonstrate that pharma-cological ischaemic preconditioning is a viable way to protect the heart from myocardial ischaemia/reperfusion (I/R) injury. This study investigated the role of hydroxychloroquine (HCQ) in the heart during I/R injury. In vitro and in vivomodels of myocardial I/R injury were used to assess the effects of HCQ. It was found that HCQ was protective in neonatal rat car-diomyocytes through inhibition of apoptosis, measured by TUNEL and cleaved caspase-3. This protection in vitro was mediated through enhancement of ERK1/2 phosphorylation mediated by HCQ in a dose-dependent fashion. A decrease in infarct size was observed in an in vivomodel of myocardial I/R inju...
Background/Aims: Troxerutin, also known as vitamin P4, has been commonly used in the treatment of ch...
Catestatin (Cst) is a 21-amino acid peptide deriving from Chromogranin A. Cst exerts an overall prot...
Abstract: The pathophysiology of cardiovascular diseases is complex and may involve oxidative stress...
An increasing number of investigations including human studies demonstrate that pharmacological isch...
An increasing number of investigations including human studies demonstrate that pharmacological isch...
<div><p>An increasing number of investigations including human studies demonstrate that pharmacologi...
Purpose Several therapeutic agents have been found to prevent myocardial ischemic and reperfusion (I...
Objective Tongxinluo (TXL) has been shown to decrease myocardial necrosis after ischemia/ reperfusio...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Background: Soluble eggshell membrane protein (SEP) has been proved to hold the antioxidant activity...
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction...
Copyright © 2015 Xu Ran et al. This is an open access article distributed under the Creative Commons...
Flavonoids are important components of ‘functional foods’, with beneficial effects on cardio-vascula...
Aim: Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reper...
Abstract: Ischemia/reperfusion injury (IRI) occurs frequently during reperfusion of ischemic myocard...
Background/Aims: Troxerutin, also known as vitamin P4, has been commonly used in the treatment of ch...
Catestatin (Cst) is a 21-amino acid peptide deriving from Chromogranin A. Cst exerts an overall prot...
Abstract: The pathophysiology of cardiovascular diseases is complex and may involve oxidative stress...
An increasing number of investigations including human studies demonstrate that pharmacological isch...
An increasing number of investigations including human studies demonstrate that pharmacological isch...
<div><p>An increasing number of investigations including human studies demonstrate that pharmacologi...
Purpose Several therapeutic agents have been found to prevent myocardial ischemic and reperfusion (I...
Objective Tongxinluo (TXL) has been shown to decrease myocardial necrosis after ischemia/ reperfusio...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Background: Soluble eggshell membrane protein (SEP) has been proved to hold the antioxidant activity...
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction...
Copyright © 2015 Xu Ran et al. This is an open access article distributed under the Creative Commons...
Flavonoids are important components of ‘functional foods’, with beneficial effects on cardio-vascula...
Aim: Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reper...
Abstract: Ischemia/reperfusion injury (IRI) occurs frequently during reperfusion of ischemic myocard...
Background/Aims: Troxerutin, also known as vitamin P4, has been commonly used in the treatment of ch...
Catestatin (Cst) is a 21-amino acid peptide deriving from Chromogranin A. Cst exerts an overall prot...
Abstract: The pathophysiology of cardiovascular diseases is complex and may involve oxidative stress...