Radiotherapy is a widely used treatment for cancer. However, recent studies suggest that ionizing radiation (IR) can promote tumor invasion and metastasis. Bmi-1, a member of the polycomb group protein family, has been observed as a regulator of oxidative stress and promotes metastasis in some tumors. But, its potential role in the metastasis induced by IR of breast cancer has not been explored. In our study, we found that increased levels of Bmi-1 were correlated to EMT of breast cancer cells. Through analyzing the EMT state and me-tastasis of breast cancer induced by IR, we found the metastatic potential of breast cancer cells can either be inhibited or accelerated by IR following a time-dependent pattern. Silenc-ing Bmi-1 completely abol...
Background: The Bmi1 polycomb ring finger oncogene, a transcriptional repressor belonging to the Pol...
Background: The Bmi1 polycomb ring finger oncogene, a transcriptional repressor belonging to the Pol...
Radiation therapy plays a critical part in cancer therapy for non-small cell lung cancers (NSCLC). H...
In some esophageal cancer patients, radiotherapy may not prevent distant metastasis thus resulting i...
Abstract: Bmi1 is a member of the polycomb group family of proteins, and it drives the carcinogenesi...
Obesity is associated with a worse breast cancer prognosis, while greater breast tumor estrogen rece...
Purpose: In our study, the glucose and cell context-dependent impact of the BMI-1 inhibitor PTC-209 ...
Despite advances in screening and treatment over the past several years, breast cancer re-mains a le...
Stroma mediated wound healing signals may share similarities with the ones produced by tumor’s micro...
a b s t r a c t 5-Fluorouracil (5-FU) is an important chemotherapeutic agent for nasopharyngeal carc...
A unique feature of cancer cells is to convert glucose into lactate to produce cellular energy, even...
Myoglobin (MB) is not only strongly expressed in myocytes, but also at much lower levels in differen...
High levels of cell surface glucose regulated protein 78 (sGRP78) have been implicated in cancer gro...
Epithelial-mesenchymal transition (EMT) is involved in the characteristics of malignancy, such as in...
Cancer is a highly dynamic disease characterized by dedifferentiation, heterogeneity, and plasticity...
Background: The Bmi1 polycomb ring finger oncogene, a transcriptional repressor belonging to the Pol...
Background: The Bmi1 polycomb ring finger oncogene, a transcriptional repressor belonging to the Pol...
Radiation therapy plays a critical part in cancer therapy for non-small cell lung cancers (NSCLC). H...
In some esophageal cancer patients, radiotherapy may not prevent distant metastasis thus resulting i...
Abstract: Bmi1 is a member of the polycomb group family of proteins, and it drives the carcinogenesi...
Obesity is associated with a worse breast cancer prognosis, while greater breast tumor estrogen rece...
Purpose: In our study, the glucose and cell context-dependent impact of the BMI-1 inhibitor PTC-209 ...
Despite advances in screening and treatment over the past several years, breast cancer re-mains a le...
Stroma mediated wound healing signals may share similarities with the ones produced by tumor’s micro...
a b s t r a c t 5-Fluorouracil (5-FU) is an important chemotherapeutic agent for nasopharyngeal carc...
A unique feature of cancer cells is to convert glucose into lactate to produce cellular energy, even...
Myoglobin (MB) is not only strongly expressed in myocytes, but also at much lower levels in differen...
High levels of cell surface glucose regulated protein 78 (sGRP78) have been implicated in cancer gro...
Epithelial-mesenchymal transition (EMT) is involved in the characteristics of malignancy, such as in...
Cancer is a highly dynamic disease characterized by dedifferentiation, heterogeneity, and plasticity...
Background: The Bmi1 polycomb ring finger oncogene, a transcriptional repressor belonging to the Pol...
Background: The Bmi1 polycomb ring finger oncogene, a transcriptional repressor belonging to the Pol...
Radiation therapy plays a critical part in cancer therapy for non-small cell lung cancers (NSCLC). H...