Add to ORKGMutations in the parkin gene are currently thought to be the most common cause of recessive familial Parkinsonism. Parkin functions as an E3 ligase to regulate protein turnover, and its function in mitochondrial quality control has been reported recently. Overexpression of parkin has been found to prevent neuronal degeneration under various conditions both in vivo and in vitro. Here, we generated a transgenic mouse model in which expression of wild type parkin was driven by neuron-specific enolase (NSE) promoter. We reported that both young and old parkin transgenic mice exhibited less reduction of striatal TH protein and number of TH positive neurons in the substantia nigra induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP), co...
BACKGROUND: Mutations in the E3 ubiquitin ligase parkin cause autosomal recessive Parkinson's diseas...
Parkinson disease causes degeneration of nigrostriatal dopamine (DA) neurons, while tuberoinfundibul...
Many mutations in genes encoding proteins such as parkin, PTEN-induced putative kinase 1 (PINK1), pr...
<div><p>Mutations in the <em>parkin</em> gene are currently thought to be the most common cause of r...
SummaryParkinson’s disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic ne...
Parkin is the most common causative gene of juvenile and early-onset familial Parkinson's diseases a...
Mutations of the parkin gene are the most frequent cause of early onset autosomal recessive parkinso...
Mutations in the PARK2 gene encoding the protein parkin cause autosomal recessive ju-venile parkinso...
International audienceBACKGROUND: Mutations of the gene encoding the major component of Lewy bodies ...
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the progressive loss...
<div><p>Parkinson’s disease (PD) is a neurodegenerative disorder of complex etiology characterized b...
Parkinson s disease (PD) is the most common neurodegenerative movement disorder. It is neuropatholog...
Loss-of-function mutations in parkin are the major cause of early-onset familial Parkinson's disease...
Mutations in the parkin gene are the most common cause of early-onset autosomal recessive Parkinson ...
Abstract Background Parkinson's disease, a prevalent neurodegenerative disease, is characterized by ...
BACKGROUND: Mutations in the E3 ubiquitin ligase parkin cause autosomal recessive Parkinson's diseas...
Parkinson disease causes degeneration of nigrostriatal dopamine (DA) neurons, while tuberoinfundibul...
Many mutations in genes encoding proteins such as parkin, PTEN-induced putative kinase 1 (PINK1), pr...
<div><p>Mutations in the <em>parkin</em> gene are currently thought to be the most common cause of r...
SummaryParkinson’s disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic ne...
Parkin is the most common causative gene of juvenile and early-onset familial Parkinson's diseases a...
Mutations of the parkin gene are the most frequent cause of early onset autosomal recessive parkinso...
Mutations in the PARK2 gene encoding the protein parkin cause autosomal recessive ju-venile parkinso...
International audienceBACKGROUND: Mutations of the gene encoding the major component of Lewy bodies ...
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the progressive loss...
<div><p>Parkinson’s disease (PD) is a neurodegenerative disorder of complex etiology characterized b...
Parkinson s disease (PD) is the most common neurodegenerative movement disorder. It is neuropatholog...
Loss-of-function mutations in parkin are the major cause of early-onset familial Parkinson's disease...
Mutations in the parkin gene are the most common cause of early-onset autosomal recessive Parkinson ...
Abstract Background Parkinson's disease, a prevalent neurodegenerative disease, is characterized by ...
BACKGROUND: Mutations in the E3 ubiquitin ligase parkin cause autosomal recessive Parkinson's diseas...
Parkinson disease causes degeneration of nigrostriatal dopamine (DA) neurons, while tuberoinfundibul...
Many mutations in genes encoding proteins such as parkin, PTEN-induced putative kinase 1 (PINK1), pr...