ORIGINAL RESEARCH ARTICLE Randomized, Double-Blind, Placebo-Controlled, Crossover Study of the Effects of Lisdexamfetamine Dimesylate and Mixed Amphetamine Salts on Cognition Throughout the Day in Adults with Attention-Deficit/Hyperactivity Disorder

The Author(s) 2013. This article is published with open access at Springerlink.com Background Understanding the nature and time course of the pharmacodynamic effects of attention-deficit/hyper-activity disorder (ADHD) medications is useful. The Cognitive Drug Research Computerized Battery of Tests (CDR-CBT) is a 20-min battery of ten standardized, vali-dated neuropsychometric tasks. Objective This pilot study examined the sensitivity and responsiveness of the CDR-CBT for assessing cognitive function in adults with ADHD prior to and up to 16 h postdose during treatment with lisdexamfetamine dimesy-late (LDX) or mixed amphetamine salts immediate release (MAS-IR; various generics available). Methods This was a double-blind three-period crossove