P-Chloroaniline Poisoning Causing Methemoglobinemia:

License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Methemoglobin (MetHb) most commonly results from exposure to an oxidizing chemical but may also arise from genetic, dietary, or even idiopathic etiologies. P-chloroaniline (PCA) was one of the first substances described in the context of acquired methemoglobinemia. Case Report. We report the case of a cyanotic chemistry worker who presented to our emergency department (ED) after working with PCA. His peripheral oxygen saturation (SpO 2) measured by pulse oximetry was at 81 % and remained on that level despite oxygen administration (100 % oxygenation via nonrebreather mask). His MetHb level was measured at 42.8 % in arterial blood gas analysis. After treatment with intravenous methylene blue cyanosis resolved and the patient was discharged after 36 hours of observation. Conclusion. Acquired methemoglobinemia is a treatable condition, which may cause significantmorbidity andmortality.The knowledge about themost common causes, fast diagnostic, and proper treatment is crucial. 1. Background Methemoglobinemia is a treatable condition that may cause significant morbidity and mortality [1]. Various systems normally operate to keep methemoglobin (MetHb) at phys