RESEARCH Ubiquitin-proteasome dep r n

Full list of author information is available at the end of the articlelence of about 1 % of population worldwide. Although many theories have been suggested to explain the neurobiology of ASD, the exact mechanism is still not understood. Recent studies indicate the role of the studies have shown an association between ASD and GABAergic system [2]. GABAA receptors mediate the fast inhibitory neurotransmission within the CNS, and most GABAA receptors are composed of 2α, 2β, and 1γ or δ-subunit [3]. GABAAα1 is expressed ubiquitously in the brain [4] and is present over 60 % of cortical GABAA receptors [5]. It is considered to be responsible for seda-* Correspondence