doi:10.1100/2012/718791 The cientificWorldJOURNAL Research Article A Study on Solubilization of Poorly Soluble Drugs by

Copyright © 2012 Sinem Göktürk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The present study is focused on the characterization of solubilization of poorly soluble drugs, that is, sulfamethoxazole (SMX) and trimethoprim (TMP) by cyclodextrins (α-, β-, and γ-CDs) and anionic surfactant sodium dodecyl sulfate (SDS). The phase solubility diagrams drawn from UV spectral measurements are of the AL type and indicate an enhancement of SMX and TMP solubility in the presence of CDs. Complex formation tendency of TMP with CDs followed the order: γ-CD> β-CD> α-C. However, the complex formation constant values, for SMX-CD system yielded the different affinity and follow the order: β-CD> γ-CD> α-CD. With taking into consideration of solubilization capacity of SDS micelles, it has been found that the solubilit