Experimental Crystal data

R factor = 0.071; wR factor = 0.215; data-to-parameter ratio = 15.6. In the title compound, C11H7F3N2O4S2, the 1,3-thiazol-2-amine residue is almost perpendicular to the central benzene ring [dihedral angle = 84.3 (2)]. There is a small twist between the benzene ring and the ester group [C—O—C—C torsion angle = 9.8 (6)]. Thus, the molecule has an L-shape. Inversion-related dimers are connected in the crystal packing by pairs of N—H N hydrogen bonds formed between the amine H and thiazole N atom via eight-membered { HNCN}2 synthons. Related literature For the biological efficacy of F and CF3 in medicinal chemistry, see: Fokin & Kolomiyets (1988); Bonacorso et al. (2006). For background to the biological applications of sulfonamides, see: Croitoru et al. (2004); Dogruer et al. (2010). For relate