RESEARCH Microrna-124 targets flotil h

Breast cancer is the leading cause of cancer death in fe-males worldwide. Due to the advances in diagnosis and tiple sequential steps that are not completely understood to date, further investigation of this mechanism is ur-Li et al. Molecular Cancer 2013, 12:163 http://www.molecular-cancer.com/content/12/1/163cell death and cell mobility [3]. Furthermore, miRNAYat-sen University, Guangzhou 510080, People’s Republic of China Full list of author information is available at the end of the articleappropriately systemic therapy, including surgery, radi-ation and chemotherapy, the prognosis of breast cancer is encouraging. However, similar to many other solid tu-mors, distant metastases account for more than 90 % of breast cancer-related death [1]. Because the underlying gently needed. MicroRNAs (miRNAs) are endogenous noncoding small RNAs that contribute to the regulation of their cognate target genes by usually imperfect base-pairing to the 3 ′ un-translated region (UTR) of a target mRNA, which results in either mRNA degradation or translation inhibition [2]. In fact, miRNAs are implicated in the regulation of various cellular processes, including proliferation, differentiation, * Correspondence