Cross-space-time clustering of childhood cancer in Great Britain: Evidence for a common aetiology

Previously, we identified space-time clustering in certain childhood cancers. This study aimed to determine whether there was cross-space-time clustering between different diagnostic groups. A total of 32,295 cases were diagnosed during 1969–1993. Cross-space-time clustering was analyzed by a second-order procedure based on Diggle’s method. Locations were birth and diagnosis addresses. The following space-time combinations were examined: address and date of birth; address at birth and date of diagnosis; address and date of diagnosis. Cross-space-time clustering analyses considered clustering pairs of cases from two different diagnostic groups. Formal statistical significance was taken as p < 0.00067 and marginal significance 0.01> p 0.00067. Based on address at birth and date of diagnosis, there was statistically significant cross-clustering between cases of HL and intracranial and intraspinal embryonal tumors (IIET), both aged 0–14 years (p < 0.0001). Based on address and date of birth, there was marginally significant cross-clustering between cases of lymphoid leukemia (LL) aged 5-14 years and Hodgkin lymphoma (HL) aged 0–14 years (p 5 0.0019). Based on address and date of diagnosis there was marginally sig-nificant cross-clustering between cases of LL aged 1–4 years and soft tissue sarcoma (STS) aged 0–14 years (p 5 0.0041). Findings from this study are consistent with possible common aetiological factors between different diagnostic groups. They suggest a common aetiology for the following pairs of diagnostic groups: HL and IIET; older cases of LL and HL; younger cases of LL and STS. The possibility of common infectious mechanisms should be explored. Space-time clustering occurs when excess numbers of cases of cancer are observed within small geographical locations at limited periods and this cannot be attributed to general excesses in those locations or at those times. We have previ-ously demonstrated statistically significant space-time cluster-ing for certain childhood cancers diagnosed in Great Britai