Metastatic Renal Cell Carcinoma to the Sinonasal Cavity: A Case Series

Renal cell carcinoma (RCC) is a relatively rare tumor, account-ing for just over 2 % of all adult malignancies as of 2008.1 Metastatic disease occurs through hematogenous spread that most often manifests in bone, lung, and the liver; however, the head and neck have been reported sites of metastasis in up to 15 % of patients.2 Metastatic disease tends to present at or near the time of initial diagnosis, but there have been reported cases of metastases to the head and neck manifest-ing greater than 10 years following primary nephrectomy.2,3 The most common site of metastatic disease in the head and neck is the thyroid gland, but the sinonasal cavity is also a frequent site, and metastases to the neck, tongue,4 facial skin, and other sites have also been reported.2,5,6 Epistaxis, facial pain, or nasal obstructionmay be the presenting symptom for patients withmetastatic RCC.7,8 Tumor in the sinonasal cavit