The effect of simvastatin o accumulation in human e l

Full list of author information is available at the end of the articleBackground Statins represent a major class of drugs for treatment of hypercholesterolemia due to their ability to inhibit de novo cholesterol synthesis, namely the rate-limiting step of mevalonate pathway catalyzed by HMG-CoA reductase. The first statin was discovered in 1976, and since 1980 they have been introduced into clinical practice [1]. In addition to their hypolipidemic effects, statins exert also numerous additional biological activities me-diated by various products of the mevalonate pathway, such as anti-inflammatory and immunomodulatory ac-tivities, effects on endothelial function, anti-oxidative effects, or effects on cell proliferation and apoptosis, etc. [2,3]. Chemoprotective effects of statins have been attrib-uted to their impact on protein prenylation. Amon