Toxic metals are part of our environment, and undue exposure to them leads to a variety of pathologies. In response, most organisms adapt their metabol-ism and have evolved systems to limit this toxicity and to acquire tolerance. Ribosome biosynthesis being central for protein synthesis, we analyzed in yeast the effects of a moderate concentration of cadmium (Cd2+) on Pol I transcription that repre-sents>60 % of the transcriptional activity of the cells. We show that Cd2+ rapidly and drastically shuts down the expression of the 35S rRNA. Repression does not result from a poisoning of any of the components of the class I transcriptional machinery by Cd2+, but rather involves a protein phosphatase 2A (PP2A)-dependent cellular signal-ing pa...
Heavy metal and metalloid contaminations are among the most concerning types of pollutant in the env...
We have explored the importance of two ATP binding domains of Hsp104 protein in protection of yeast ...
Copper is essential to all organisms at relatively low levels, but is toxic at high intracellular co...
Regulation of gene expression at the messenger RNA (mRNA) level is vital for initiating a rapid and ...
Cadmium (Cd) is a toxic heavy metal mainly originating from industrial activities and causes environ...
Although considered as essential cofactors for a variety of enzymatic reactions and for important st...
Cadmium is a highly toxic environmental contaminant implicated in various diseases. Our previous dat...
International audienceCadmium (Cd2+) is a very toxic metal that causes DNA damage, oxidative stress ...
Although considered as essential cofactors for a variety of enzymatic reactions and for important st...
<div><p>Although considered as essential cofactors for a variety of enzymatic reactions and for impo...
Detoxification and homeostatic acquisition of metal ions are vital for all living organisms. Non-phy...
Stress-activated protein kinases and transcription factors are crucial for surviving exposure to cad...
International audienceTo study the impact of translational regulation during heavy metal poisoning, ...
AbstractCadmium (Cd2+) is a toxic heavy metal which triggers several toxic effects in eukaryotes, in...
Heavy metal and metalloid contaminations are among the most concerning types of pollutant in the env...
Heavy metal and metalloid contaminations are among the most concerning types of pollutant in the env...
We have explored the importance of two ATP binding domains of Hsp104 protein in protection of yeast ...
Copper is essential to all organisms at relatively low levels, but is toxic at high intracellular co...
Regulation of gene expression at the messenger RNA (mRNA) level is vital for initiating a rapid and ...
Cadmium (Cd) is a toxic heavy metal mainly originating from industrial activities and causes environ...
Although considered as essential cofactors for a variety of enzymatic reactions and for important st...
Cadmium is a highly toxic environmental contaminant implicated in various diseases. Our previous dat...
International audienceCadmium (Cd2+) is a very toxic metal that causes DNA damage, oxidative stress ...
Although considered as essential cofactors for a variety of enzymatic reactions and for important st...
<div><p>Although considered as essential cofactors for a variety of enzymatic reactions and for impo...
Detoxification and homeostatic acquisition of metal ions are vital for all living organisms. Non-phy...
Stress-activated protein kinases and transcription factors are crucial for surviving exposure to cad...
International audienceTo study the impact of translational regulation during heavy metal poisoning, ...
AbstractCadmium (Cd2+) is a toxic heavy metal which triggers several toxic effects in eukaryotes, in...
Heavy metal and metalloid contaminations are among the most concerning types of pollutant in the env...
Heavy metal and metalloid contaminations are among the most concerning types of pollutant in the env...
We have explored the importance of two ATP binding domains of Hsp104 protein in protection of yeast ...
Copper is essential to all organisms at relatively low levels, but is toxic at high intracellular co...