Add to ORKGfalciparum; plyamines; structure-based drug design; malaria. PDB references: spermidine synthase, complex with dcAdoMet and 4MAN, 4bp3; complex with MTA and putrescine, 4bp1; complex with MTA and 4AMA, 4uoe; complex with MTA and spermidine, 4cxm; complex with BIPA, 4cwa Supporting information: this article has supporting information at journals.iucr.org/d Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug desig
The treatment of malaria, the most common parasitic disease worldwide and the third deadliest infect...
This dissertation describes the progress made in the development of compounds with in vitro potency ...
Malaria is an infectious disease caused by a diverse group of erythrocytic protozoan parasites of th...
Background: Plasmodium falciparum is the most pathogenic of the human malaria parasite species and a...
The enzymes of the polyamine-biosynthesis pathway have been proposed to be promising drug targets in...
Plasmodium falciparum is the causative agent of the most severe type of malaria, a life-threatening ...
Malaria, caused by the protozoan parasite Plasmodium falciparum is responsible for about 600.000 dea...
Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ...
The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in pr...
Malaria is an infectious disease that is responsible for approximately one million deaths across the...
Malaria is a deadly disease killing worldwide hundreds of thousands people each year and the respons...
The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in pr...
Plasmepsins (Plms) are aspartic proteases involved in the degradation of human hemoglobin by Plasmod...
Malaria is one of the major public health problems in the world. Approximately 500 million people ar...
Malaria is a parasitic disease that remains a global health burden. The ability of the parasite to r...
The treatment of malaria, the most common parasitic disease worldwide and the third deadliest infect...
This dissertation describes the progress made in the development of compounds with in vitro potency ...
Malaria is an infectious disease caused by a diverse group of erythrocytic protozoan parasites of th...
Background: Plasmodium falciparum is the most pathogenic of the human malaria parasite species and a...
The enzymes of the polyamine-biosynthesis pathway have been proposed to be promising drug targets in...
Plasmodium falciparum is the causative agent of the most severe type of malaria, a life-threatening ...
Malaria, caused by the protozoan parasite Plasmodium falciparum is responsible for about 600.000 dea...
Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ...
The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in pr...
Malaria is an infectious disease that is responsible for approximately one million deaths across the...
Malaria is a deadly disease killing worldwide hundreds of thousands people each year and the respons...
The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in pr...
Plasmepsins (Plms) are aspartic proteases involved in the degradation of human hemoglobin by Plasmod...
Malaria is one of the major public health problems in the world. Approximately 500 million people ar...
Malaria is a parasitic disease that remains a global health burden. The ability of the parasite to r...
The treatment of malaria, the most common parasitic disease worldwide and the third deadliest infect...
This dissertation describes the progress made in the development of compounds with in vitro potency ...
Malaria is an infectious disease caused by a diverse group of erythrocytic protozoan parasites of th...