The kinase TAK is required for the development of conventional and regulatory T cells. We previously reported that mice with conditional deletion of TAK1 in T cells (Lck-cre: TAK1fl/fl mice) exhibited severe T lymphopenia, and were nevertheless predisposed to spontaneous colitis with unknown etiology. Here we focused on the immunopathological mechanism in colitic Lck-cre:TAK1fl/fl mice. We found that ‘leaky ’ CD4+ T cells retaining TAK1 acquired inflammatory phenotypes that contribute to disease onset in Lck-cre:TAK1fl/fl mice. Furthermore, the gut microbiota-triggered signaling was also a key event leading to the pathogenesis. We discovered that Lck-cre:TAK1fl/fl mice were almost completely devoid of TCRαβ+CD8α+ intestinal intraepithelial ...
Background and Aims: Regulatory Foxp3(+) CD4(+) T cells [Tregs] have been implicated in the control ...
TL1A is a proinflammatory cytokine, which is prevalent in the gut. High TL1A concentrations are pres...
SummaryStringent control of NF-κB and mitogen-activated protein kinase (MAPK) signaling is critical ...
The kinase TAK is required for the development of conventional and regulatory T cells. We previously...
<div><p>The kinase TAK is required for the development of conventional and regulatory T cells. We pr...
We have previously reported that intestinal epithelium-specific TAK1 deleted mice exhibit severe inf...
Recent studies have revealed that TAK1 kinase is an essential intermediate in several innate immune ...
BackgroundWe have previously reported that intestinal epithelium-specific TAK1 deleted mice exhibit ...
SummaryImmune tolerance against enteric commensal bacteria is important for preventing intestinal in...
BACKGROUND & AIMS: Nuclear factor of activated T cells transcription factors plays a central role in...
The recent explosion of transgenic and targeted gene deleted (knockout [KO]) rodents has yielded a n...
SummaryCD8αα+ intraepithelial lymphocytes (IELs) are instrumental in maintaining the epithelial barr...
Thymic stromal lymphopoietin (TSLP) is produced by epithelial cells and keratinocytes, and is involv...
Inflammatory bowel disease (IBD) comprising Crohn s disease and ulcerative colitis is a disease that...
Background: The intestinal epithelium accommodates with a myriad of commensals to maintain immunolog...
Background and Aims: Regulatory Foxp3(+) CD4(+) T cells [Tregs] have been implicated in the control ...
TL1A is a proinflammatory cytokine, which is prevalent in the gut. High TL1A concentrations are pres...
SummaryStringent control of NF-κB and mitogen-activated protein kinase (MAPK) signaling is critical ...
The kinase TAK is required for the development of conventional and regulatory T cells. We previously...
<div><p>The kinase TAK is required for the development of conventional and regulatory T cells. We pr...
We have previously reported that intestinal epithelium-specific TAK1 deleted mice exhibit severe inf...
Recent studies have revealed that TAK1 kinase is an essential intermediate in several innate immune ...
BackgroundWe have previously reported that intestinal epithelium-specific TAK1 deleted mice exhibit ...
SummaryImmune tolerance against enteric commensal bacteria is important for preventing intestinal in...
BACKGROUND & AIMS: Nuclear factor of activated T cells transcription factors plays a central role in...
The recent explosion of transgenic and targeted gene deleted (knockout [KO]) rodents has yielded a n...
SummaryCD8αα+ intraepithelial lymphocytes (IELs) are instrumental in maintaining the epithelial barr...
Thymic stromal lymphopoietin (TSLP) is produced by epithelial cells and keratinocytes, and is involv...
Inflammatory bowel disease (IBD) comprising Crohn s disease and ulcerative colitis is a disease that...
Background: The intestinal epithelium accommodates with a myriad of commensals to maintain immunolog...
Background and Aims: Regulatory Foxp3(+) CD4(+) T cells [Tregs] have been implicated in the control ...
TL1A is a proinflammatory cytokine, which is prevalent in the gut. High TL1A concentrations are pres...
SummaryStringent control of NF-κB and mitogen-activated protein kinase (MAPK) signaling is critical ...