MiR-21: an environmental driver of malignant melanoma? Bodo C Melnik* Since the mid-1950’s, melanoma incidence has been rising steadily in industrialized Caucasian populations, thereby pointing to the pivotal involvement of environmental factors in melanomagenesis. Recent evidence underlines the crucial role of microRNA (miR) signaling in cancer initiation and progression. Increased miR-21 expression has been observed during the transition from a benign melanocytic lesion to malignant melanoma, exhibiting highest expres-sion of miR-21. Notably, common BRAF and NRAS mutations in cutaneous melanoma are associated with increased miR-21 expression. MiR-21 is an oncomiR that affects critical target genes of malignant melanoma, resulting in susta...
The non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns. They down-re...
When it escapes early detection, malignant melanoma becomes a highly lethal and treatment-refractory...
The non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns. They down-re...
DNA mutation-induced activation of RAS-BRAF-MEK-ERK signaling associated with intermittent or chroni...
DNA mutation-induced activation of RAS-BRAF-MEK-ERK signaling associated with intermittent or chroni...
<div><p>Metastatic melanoma is the most aggressive form of this cancer. It is important to understan...
The immediate molecular mechanisms behind invasive melanoma are poorly understood. Recent studies im...
peer reviewedThe non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns....
peer reviewedThe non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns....
<div><p>The non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns. They...
Cutaneous melanoma is associated with significant morbidity and mortality representing the most sign...
To identify microRNAs potentially involved in melanomagenesis, we compared microRNA expression profi...
The incidence of melanoma has continually increased mortality rates over the past decade in the Unit...
The incidence of melanoma has continually increased mortality rates over the past decade in the Unit...
P>To identify microRNAs potentially involved in melanomagenesis, we compared microRNA expression pro...
The non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns. They down-re...
When it escapes early detection, malignant melanoma becomes a highly lethal and treatment-refractory...
The non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns. They down-re...
DNA mutation-induced activation of RAS-BRAF-MEK-ERK signaling associated with intermittent or chroni...
DNA mutation-induced activation of RAS-BRAF-MEK-ERK signaling associated with intermittent or chroni...
<div><p>Metastatic melanoma is the most aggressive form of this cancer. It is important to understan...
The immediate molecular mechanisms behind invasive melanoma are poorly understood. Recent studies im...
peer reviewedThe non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns....
peer reviewedThe non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns....
<div><p>The non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns. They...
Cutaneous melanoma is associated with significant morbidity and mortality representing the most sign...
To identify microRNAs potentially involved in melanomagenesis, we compared microRNA expression profi...
The incidence of melanoma has continually increased mortality rates over the past decade in the Unit...
The incidence of melanoma has continually increased mortality rates over the past decade in the Unit...
P>To identify microRNAs potentially involved in melanomagenesis, we compared microRNA expression pro...
The non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns. They down-re...
When it escapes early detection, malignant melanoma becomes a highly lethal and treatment-refractory...
The non-coding microRNAs (miRNA) have tissue- and disease-specific expression patterns. They down-re...