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NDMETHODS:Human ovarian carcinoma cells producing high (SKOV3ip1) or low (HeyA8) levels of VEGF were implanted into the peritoneal cavity of female nude mice. Seven days later, micewere randomized into four groups: control (ve ion], rhLK8 (50 mg/kg, daily i.p. injection), or the combination and examined by necropsy. RESULTS: In mice implanted wit t on tumor incidenceor the volumeof ascites but induced a sig ice. Paclitaxel significantly reduced tumor weight and ascites LK8 had an additive therapeutic effect. Similarly, in HeyA8 m and tumor incidence was statistically significantly greater t ical analysis showed a significant decrease in microvessel de mor-associated endothelial cells in response to combination tr vely, www.transonc.co