Background: FFAR1 receptor is a long chain fatty acid G-protein coupled receptor which is expressed widely, but found in high density in the pancreas and central nervous system. It has been suggested that FFAR1 may play a role in insulin sensitivity, lipotoxicity and is associated with type 2 diabetes. Here we investigate the effect of three common SNPs of FFAR1 (rs2301151; rs16970264; rs1573611) on pancreatic function, BMI, body composition and plasma lipids. Methodology/Principal Findings: For this enquiry we used the baseline RISCK data, which provides a cohort of overweight subjects at increased cardiometabolic risk with detailed phenotyping. The key findings were SNPs of the FFAR1 gene region were associated with differences in body co...
Background: As nuclear receptors and transcription factors have an important regulatory function in ...
Background: As nuclear receptors and transcription factors have an important regulatory function in ...
Objective: A genome-wide association study conducted by the Wellcome Trust Case Control Consortium r...
Background FFAR1 receptor is a long chain fatty acid G-protein coupled receptor which is expressed w...
Background FFAR1 receptor is a long chain fatty acid G-protein coupled receptor which is expressed ...
(rs2301151; rs16970264; rs1573611) on pancreatic function, BMI, body composition and plasma lipids....
BACKGROUND: The FFAR1 receptor is expressed mainly in pancreatic beta cells and is activated by medi...
The role of free fatty acid receptor 1 (FFAR1/GPR40) in glucose homeostasis is still incompletely un...
International audienceBackground We previously reported that the low-frequency, loss-of-function var...
Genetic variation in FFAR1 modulates insulin secretion dependent on non-esterified fatty acid (NEFA)...
Deteriorating beta-cell function is a common feature of type 2 diabetes. In this review, we briefly ...
Objective: The fatty acid receptor 1 (FFAR1/GPR40) mediates fatty acid-dependent augmentation of glu...
Many common diseases such as obesity and type-2 diabetes have a significant genetic component that c...
This is the author accepted manuscript. The final version is available from Elsevier via the DOI in ...
Objective:Much of the genetic variation in glucose levels remains to be discovered. Especially, rese...
Background: As nuclear receptors and transcription factors have an important regulatory function in ...
Background: As nuclear receptors and transcription factors have an important regulatory function in ...
Objective: A genome-wide association study conducted by the Wellcome Trust Case Control Consortium r...
Background FFAR1 receptor is a long chain fatty acid G-protein coupled receptor which is expressed w...
Background FFAR1 receptor is a long chain fatty acid G-protein coupled receptor which is expressed ...
(rs2301151; rs16970264; rs1573611) on pancreatic function, BMI, body composition and plasma lipids....
BACKGROUND: The FFAR1 receptor is expressed mainly in pancreatic beta cells and is activated by medi...
The role of free fatty acid receptor 1 (FFAR1/GPR40) in glucose homeostasis is still incompletely un...
International audienceBackground We previously reported that the low-frequency, loss-of-function var...
Genetic variation in FFAR1 modulates insulin secretion dependent on non-esterified fatty acid (NEFA)...
Deteriorating beta-cell function is a common feature of type 2 diabetes. In this review, we briefly ...
Objective: The fatty acid receptor 1 (FFAR1/GPR40) mediates fatty acid-dependent augmentation of glu...
Many common diseases such as obesity and type-2 diabetes have a significant genetic component that c...
This is the author accepted manuscript. The final version is available from Elsevier via the DOI in ...
Objective:Much of the genetic variation in glucose levels remains to be discovered. Especially, rese...
Background: As nuclear receptors and transcription factors have an important regulatory function in ...
Background: As nuclear receptors and transcription factors have an important regulatory function in ...
Objective: A genome-wide association study conducted by the Wellcome Trust Case Control Consortium r...