RESEARCH ARTICLE Ectopic lymphoid neogen associated with activation y

os Ectopic lymphoid neogenesis (ELN) is a histological feature describing the organized aggregation in nonlym-ovial tissue (ST) in rheumatoid arthritis (RA) as well as other forms of inflammatory arthritis [3–5]. ELN is asso-nt to induce ecific micro-N suggests a utoimmunity indicates that Cañete et al. Arthritis Research & Therapy (2015) 17:173 DOI 10.1186/s13075-015-0688-0between synovial ELN and systemic or local RA-specific antibodies [5, 13, 14]. Moreover, the presence of synovia