RESEARCH ARTICLE Open Access Dose-response relationshi m o

Full list of author information is available at the end of the articlesystemic cancer therapy for half a century. On the basis of the concept that a given dose of an antineoplastic compound would destroy a certain fraction of tumor cells, the efficiency of tumor chemotherapy, to a great extent, is dependent on the dosage of drugs and higher doses are supposed to be more effective. Therefore, high-dose chemotherapy with autologous bone-marrow [1,2]. However, high-dose chemotherapy in solid tumor in order to boost the effect of anti-cancer therapy is al-ways under controversy. The studies of Leonard RC and Roche H et al. showed that high-dose chemotherapy with autologous bone-marrow stem-cell transplants had not improved the overall survival and disease free sur-vival as expected, when used for patients with metastatic breast cancer [3,4]. Moreover, this approach is also very expensive and highly toxic. Thus, exactly assessing tumor response to different dose of chemotherapy is ur-gently needed, which could not only be helpful to tailo