Arterial Stiffness Is Inversely Related to Plasma Adiponectin Levels in Young Normotensive PatientsWith Type 1 Diabetes

OBJECTIVEdThis study investigated the association between arterial stiffness and plasma adiponectin in patients with type 1 diabetes. RESEARCH DESIGN ANDMETHODSdParticipants were normotensive patients with type 1 diabetes who were up to age 40 years. Subjects on statins with macrovascular disease or overt nephropathy were excluded. Large artery stiffness was assessed bymeasurement of carotid-femoral pulse wave velocity (PWV), whereas plasma adiponectin was measured by radioimmu-noassay. RESULTSdData from 80 patients (age 27.16 6.1 years, BMI 24.26 3.1 kg/m2, HbA1c 7.56 1.6%, 39 men, adiponectin 13.9 6 6.7 mg/mL, and PWV 5.6 6 0.9 m/s) were analyzed. Log adiponectin inversely correlated with age-adjusted PWV (r = 20.291, P = 0.009) and waist circumference (r = 20.427, P, 0.001). In a fully adjusted model, age, expiration/inspiration index, and log adiponectin were independently associated with PWV, explaining 39.6 % of its variance. CONCLUSIONSdArterial stiffness is inversely related to adiponectin concentration in young patients with type 1 diabetes without major complications