The modern synthetic view of human evolution proposes that the fixation of novel mutations is driven by the balance among selective advantage, selective disadvantage, and genetic drift. When considering the global architecture of the human genome, the same model can be applied to understanding the rapid acquisition and proliferation of exogenous DNA. To explore the evolutionary forces that might have morphed human genome architecture, we investigated the origin, composition, and functional potential of numts (nuclear mitochondrial pseudogenes), partial copies of the mitochondrial genome found abundantly in chromosomal DNA. Our data indicate that these elements are unlikely to be advantageous, since they possess no gross positional, transcri...
Mildly deleterious mutations initially contribute to the diversity of a population, but later they a...
Mitochondrial DNA is one of the most explored genetic systems because of what it can tell us about t...
Human segmental duplications are hotspots for nonallelic homologous recombination leading to genomic...
Fragments of mitochondrial DNA are known to get inserted into nuclear DNA to form NUMTs, i.e. nuclea...
The hypothesis that the evolution of humans involves hybridization between diverged species has been...
bstract The human genome is constantly subjected to evolutionary forces which shape its architect...
Fragments of mitochondrial DNA (mtDNA) have inserted into their respective nuclear genomes multiple ...
The human genome is constantly subjected to evolutionary forces which shape its architecture. Insert...
Human evolution exhibits repeated speciations and conspicuous morphological change: from Australopit...
<div><p>Integration of mitochondrial DNA fragments into nuclear chromosomes (giving rise to nuclear ...
The recent breathtaking progress in whole genome sequencing technology allows access to the genomes ...
Integration of mitochondrial DNA fragments into nuclear chromosomes (giving rise to nuclear DNA sequ...
As the number of whole genomes available for study increases, so also does the opportunity to find u...
The landscape of the human genome consists of millions of short islands of conservation that are 100...
The molecular clock of mitochondrial DNA has been extensively used to date various genetic events. H...
Mildly deleterious mutations initially contribute to the diversity of a population, but later they a...
Mitochondrial DNA is one of the most explored genetic systems because of what it can tell us about t...
Human segmental duplications are hotspots for nonallelic homologous recombination leading to genomic...
Fragments of mitochondrial DNA are known to get inserted into nuclear DNA to form NUMTs, i.e. nuclea...
The hypothesis that the evolution of humans involves hybridization between diverged species has been...
bstract The human genome is constantly subjected to evolutionary forces which shape its architect...
Fragments of mitochondrial DNA (mtDNA) have inserted into their respective nuclear genomes multiple ...
The human genome is constantly subjected to evolutionary forces which shape its architecture. Insert...
Human evolution exhibits repeated speciations and conspicuous morphological change: from Australopit...
<div><p>Integration of mitochondrial DNA fragments into nuclear chromosomes (giving rise to nuclear ...
The recent breathtaking progress in whole genome sequencing technology allows access to the genomes ...
Integration of mitochondrial DNA fragments into nuclear chromosomes (giving rise to nuclear DNA sequ...
As the number of whole genomes available for study increases, so also does the opportunity to find u...
The landscape of the human genome consists of millions of short islands of conservation that are 100...
The molecular clock of mitochondrial DNA has been extensively used to date various genetic events. H...
Mildly deleterious mutations initially contribute to the diversity of a population, but later they a...
Mitochondrial DNA is one of the most explored genetic systems because of what it can tell us about t...
Human segmental duplications are hotspots for nonallelic homologous recombination leading to genomic...