Symptoms in People with Psychotic Disorders: A Meta-Analysis

Aims: The aim of this study was to estimate the effects of lifestyle interventions on bodyweight and other cardiometabolic risk factors in people with psychotic disorders. Additionally, the long-term effects on body weight and the effects on depressive symptoms were examined. Material and Methods: We searched four databases for randomized controlled trials (RCTs) that compared lifestyle interventions to control conditions in patients with psychotic disorders. Lifestyle interventions were aimed at weight loss or weight gain prevention, and the study outcomes included bodyweight or metabolic parameters. Results: The search resulted in 25 RCTs-only 4 were considered high quality-showing an overall effect of lifestyle interventions on bodyweight (effect size (ES)520.63, p,0.0001). Lifestyle interventions were effective in both weight loss (ES520.52, p,0.0001) and weight-gain-prevention (ES520.84, p50.0002). There were significant long-term effects, two to six months post-intervention, fo