Background: Aberrantly elevated sterol regulatory element binding protein (SREBP), the lipogenic transcription factor, contributes to the development of fatty liver and insulin resistance in animals. Our recent studies have discovered that AMP-activated protein kinase (AMPK) phosphorylates SREBP at Ser-327 and inhibits its activity, represses SREBP-dependent lipogenesis, and thereby ameliorates hepatic steatosis and atherosclerosis in insulin-resistant LDLR2/2 mice. Chronic inflammation and activation of NLRP3 inflammasome have been implicated in atherosclerosis and fatty liver disease. However, whether SREBP is involved in vascular lipid accumulation and inflammation in atherosclerosis remains largely unknown. Principal Findings: The precl...
Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthes...
Sterol regulatory element-binding protein-1 (SREBP-1) is a key transcription factor that regulates g...
Background/Aims: Sterol regulatory element-binding protein (SREBP) 1, the master regulator of lipoge...
Aberrantly elevated sterol regulatory element binding protein (SREBP), the lipogenic transcription f...
mice. Chronic inflammation and activation of NLRP3 inflammasome have been implicated in atheroscler...
<p>Prolonged hyperglycemia causes the integrated suppression of arterial SIRT1 and AMPK in the devel...
International audienceAMPK has emerged as a critical mechanism for salutary effects of polyphenols o...
SummaryAMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid metabol...
<p><b>A</b>. The transcriptional regulation of <i>de novo</i> lipogenic enzymes (blue color) by SREB...
Liver steatosis is associated with hepatic insulin resistance. SREBP1c is a transcription factor tha...
Hypercholesterolemia is a well-established risk factor for atherosclerotic cardiovascular disease (A...
Pulmonary inflammation is associated with altered lipid synthesis and clearance related to diabetes,...
Background-The molecular basis for the focal nature of atherosclerotic lesions is poorly understood....
<p><b>A–C</b>. expression of NLRP3 and apoptosis-associated speck-like protein (ASC) is increased in...
The key lipid metabolism transcription factor sterol regulatory element-binding protein (SREBP)-1a i...
Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthes...
Sterol regulatory element-binding protein-1 (SREBP-1) is a key transcription factor that regulates g...
Background/Aims: Sterol regulatory element-binding protein (SREBP) 1, the master regulator of lipoge...
Aberrantly elevated sterol regulatory element binding protein (SREBP), the lipogenic transcription f...
mice. Chronic inflammation and activation of NLRP3 inflammasome have been implicated in atheroscler...
<p>Prolonged hyperglycemia causes the integrated suppression of arterial SIRT1 and AMPK in the devel...
International audienceAMPK has emerged as a critical mechanism for salutary effects of polyphenols o...
SummaryAMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid metabol...
<p><b>A</b>. The transcriptional regulation of <i>de novo</i> lipogenic enzymes (blue color) by SREB...
Liver steatosis is associated with hepatic insulin resistance. SREBP1c is a transcription factor tha...
Hypercholesterolemia is a well-established risk factor for atherosclerotic cardiovascular disease (A...
Pulmonary inflammation is associated with altered lipid synthesis and clearance related to diabetes,...
Background-The molecular basis for the focal nature of atherosclerotic lesions is poorly understood....
<p><b>A–C</b>. expression of NLRP3 and apoptosis-associated speck-like protein (ASC) is increased in...
The key lipid metabolism transcription factor sterol regulatory element-binding protein (SREBP)-1a i...
Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthes...
Sterol regulatory element-binding protein-1 (SREBP-1) is a key transcription factor that regulates g...
Background/Aims: Sterol regulatory element-binding protein (SREBP) 1, the master regulator of lipoge...