Comparison of conventional Papanicolaou cytology samples with liquid-based cervical cytology samples

In the present study, we compared the performance of a ThinPrep cytological method with the conventional Papanicolaou test for diagnosis of cytopathological changes, with regard to unsatisfactory results achieved at the Central Public Health Laboratory of the State of Pernambuco. A population-based, cross-sectional study was performed with women aged 18 to 65 years, who spontaneously sought gynecological services in Public Health Units in the State of Pernambuco, Northeast Brazil, between April and November 2011. All patients in the study were given a standardized questionnaire on socio-demographics, sexual characteristics, reproductive practices, and habits. A total of 525 patients were assessed by the two methods (11.05 % were under the age of 25 years, 30.86 % were single, 4.4 % had had more than 5 sexual partners, 44% were not using contraception, 38.85 % were users of alcohol, 24.38 % were smokers, 3.24 % had consumed drugs previously, 42.01 % had gynecological complaints, and 12.19 % had an early history of sexually transmitted diseases). The two methods showed poor correlation (k=0.19; 95%CI=0.11-0.26; Po0.001). The ThinPrep method reduced the rate of unsatisfactory results from 4.38 % to 1.71 % (w2=5.28; P=0.02), and the number of cytopathological changes diagnosed increased from 2.47 % to 3.04%. This study confirmed that adopting the ThinPrep method for diagnosis of cervical cytological samples was an improvement over the conventional method. Furthermore, this method may reduce possible losses from cytological resampling and reduce obstacles to patient follow-up, improving the quality of the public health system in the State o