RESEARCH ARTICLE Expression of A disintegrin

Full list of author information is available at the end of the articleBackground Colorectal cancer (CRC) is the third most common cancer and the fifth leading cause of cancer-related deaths, with approximately 715,000 new cases and 70,000 deaths annually in China. The survival of CRC patients is closely correlated with conventional and clinicopathological characteristics, such as tumor location, differentiation grade and TNM stages [1]. However, in practice, CRC patients with the same pathological features may have different prognosis. To discover new treatment options and more precise assessment of this malignancy, some potential therapy targets and candidate biomarkers have been re-ported, such as adenomatous polyposis coli (APC) gene, K-RAS gene, p53 gene and microsatellite instability (MSI) [2]. Among these targets and candidate biomarkers, some are used to justify whether adjuvant therapy is suitable for individual CRC patients, including MSI and wild-type o