Add to ORKGBackground Contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired acute renal failure. Oxidative stress, apoptosis and inflammation play crucial roles in CIN. Rena-lase is a newly discovered monoamine oxidase from the kidney. We hypothesize that rena-lase could protect against CIN through anti-oxidation, anti-inflammation and anti-apoptosis pathways. Methods We tested our hypothesis in vivo with a rat model of Ioversol-induced CIN and in vitro. Spra-gue-Dawley rats were divided into 4 groups (n = 6 per group): control group, Ioversol group (rats subjected to Ioversol-induced CIN), Ioversol plus vehicle group (CIN rats pretreated with vehicle) and Ioversol plus renalase group (CIN rats pretreated with 2 mg/kg reco...
Ischemia/reperfusion (I/R) is a major cause of acute kidney injury. Several studies have shown that ...
Many studies proposed that oxidative stress and apoptosis are key mechanisms in the pathogenesis of ...
Background. Altered renal vasodilatation and oxidative stress are important mechanisms of contrast-i...
Contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired acute renal failu...
Background. Oxidative stress plays an important role in the pathogenesis of contrast-induced nephrop...
To investigate the unrecognized role of renal efferent nerve activity (RENA) in iodinated contrast m...
Background: Renal vasoconstriction, activated by the reninangiotensin system, plays a pivotal role i...
The present study investigated the possible renoprotective effect of direct renin inhibitor (aliskir...
Background: Renal vasoconstriction, activated by the reninangiotensin system, plays a pivotal role i...
Contrast media- (CM-) induced nephropathy is a serious complication of radiodiagnostic procedures. A...
Contrast is widely used in invasive image examinations such as computed tomography (CT) and angiogra...
Background: Contrast-induced nephropathy (CIN) refers to acute renal damage that occurs after the us...
Locally generated angiotensin II (AngII) may be involved in the pathogenic mechanisms of chronic ren...
Background/Aims: Tanshinone IIA is a chemical compound extracted from Salvia miltiorrhiza Bunge, a p...
Background: Contrast media (CM)-induced nephropathy (CIN) is an acute deterioration of renal functio...
Ischemia/reperfusion (I/R) is a major cause of acute kidney injury. Several studies have shown that ...
Many studies proposed that oxidative stress and apoptosis are key mechanisms in the pathogenesis of ...
Background. Altered renal vasodilatation and oxidative stress are important mechanisms of contrast-i...
Contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired acute renal failu...
Background. Oxidative stress plays an important role in the pathogenesis of contrast-induced nephrop...
To investigate the unrecognized role of renal efferent nerve activity (RENA) in iodinated contrast m...
Background: Renal vasoconstriction, activated by the reninangiotensin system, plays a pivotal role i...
The present study investigated the possible renoprotective effect of direct renin inhibitor (aliskir...
Background: Renal vasoconstriction, activated by the reninangiotensin system, plays a pivotal role i...
Contrast media- (CM-) induced nephropathy is a serious complication of radiodiagnostic procedures. A...
Contrast is widely used in invasive image examinations such as computed tomography (CT) and angiogra...
Background: Contrast-induced nephropathy (CIN) refers to acute renal damage that occurs after the us...
Locally generated angiotensin II (AngII) may be involved in the pathogenic mechanisms of chronic ren...
Background/Aims: Tanshinone IIA is a chemical compound extracted from Salvia miltiorrhiza Bunge, a p...
Background: Contrast media (CM)-induced nephropathy (CIN) is an acute deterioration of renal functio...
Ischemia/reperfusion (I/R) is a major cause of acute kidney injury. Several studies have shown that ...
Many studies proposed that oxidative stress and apoptosis are key mechanisms in the pathogenesis of ...
Background. Altered renal vasodilatation and oxidative stress are important mechanisms of contrast-i...