Insulin Sensitivity in Healthy YoungMen: A Randomized Controlled Trial.

A recent article by Aeberli et al. (1)concluded that moderate amountsof fructose and sucrose “clearly” and significantly alter hepatic insulin sen-sitivity and lipid metabolism compared with glucose. The authors ’ data do not support their conclusions, however, due to experimental design limitations, data variability, and undemonstrated clinical significance at moderate fructose doses. First, the authors properly reported baseline daily intake data for energy, sugars, and fibers in Table 3 of ref. 1 but neglected to do so for the crux of the article—the metabolic markers and mea-sures of glucose metabolism reported in Tables 1 and 2 of ref. 1. Although th