The phosphopantetheinyl transferases (PPTases) are responsible for the activation of the carrier protein domains of the polyketide synthases (PKS), non ribosomal peptide synthases (NRPS) and fatty acid synthases (FAS). The analysis of the Streptomyces ambofaciens ATCC23877 genome has revealed the presence of four putative PPTase encoding genes. One of these genes appears to be essential and is likely involved in fatty acid biosynthesis. Two other PPTase genes, samT0172 (alpN) and samL0372, are located within a type II PKS gene cluster responsible for the kinamycin production and an hybrid NRPS-PKS cluster involved in antimycin production, respectively, and their products were shown to be specifically involved in the biosynthesis of these se...
There is a constant need for new and improved drugs to combat infectious diseases, cancer, and other...
Phosphopantetheinyl transferase (PPTase) enzymes fulfil essential roles in primary and secondary met...
Streptomycetes exhibit genetic multiplicity, like many other microorganisms, and redundancy occurs i...
The phosphopantetheinyl transferases (PPTases) are responsible for the activation of the carrier pro...
<div><p>The phosphopantetheinyl transferases (PPTases) are responsible for the activation of the car...
AbstractBackground: Phosphopantetheinyl transferases (PPTases) catalyze the posttranslational modifi...
BackgroundNonribosomal peptide synthetases (NRPSs) catalyze the assembly of a structurally diverse g...
I. ABSTRACT in English The presented work is focused on secondary metabolism and its regulation in S...
SummaryFostriecin is a unique phosphate monoester antibiotic that was isolated from Streptomyces pul...
Analysis of the gene cluster from Streptomyces hygroscopicus that governs the biosypthesis of the po...
Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Strept...
The emergence of antibiotic resistance poses a threat to humankind in combination with the significa...
Streptomyces spp. are known to produce various types of biologically active compounds including anti...
International audienceIn Streptomyces, antibiotic biosynthesis is triggered in phosphate limitation ...
The genome sequence of Streptomyces ambofaciens, a species known to produce the congocidine and spir...
There is a constant need for new and improved drugs to combat infectious diseases, cancer, and other...
Phosphopantetheinyl transferase (PPTase) enzymes fulfil essential roles in primary and secondary met...
Streptomycetes exhibit genetic multiplicity, like many other microorganisms, and redundancy occurs i...
The phosphopantetheinyl transferases (PPTases) are responsible for the activation of the carrier pro...
<div><p>The phosphopantetheinyl transferases (PPTases) are responsible for the activation of the car...
AbstractBackground: Phosphopantetheinyl transferases (PPTases) catalyze the posttranslational modifi...
BackgroundNonribosomal peptide synthetases (NRPSs) catalyze the assembly of a structurally diverse g...
I. ABSTRACT in English The presented work is focused on secondary metabolism and its regulation in S...
SummaryFostriecin is a unique phosphate monoester antibiotic that was isolated from Streptomyces pul...
Analysis of the gene cluster from Streptomyces hygroscopicus that governs the biosypthesis of the po...
Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Strept...
The emergence of antibiotic resistance poses a threat to humankind in combination with the significa...
Streptomyces spp. are known to produce various types of biologically active compounds including anti...
International audienceIn Streptomyces, antibiotic biosynthesis is triggered in phosphate limitation ...
The genome sequence of Streptomyces ambofaciens, a species known to produce the congocidine and spir...
There is a constant need for new and improved drugs to combat infectious diseases, cancer, and other...
Phosphopantetheinyl transferase (PPTase) enzymes fulfil essential roles in primary and secondary met...
Streptomycetes exhibit genetic multiplicity, like many other microorganisms, and redundancy occurs i...