CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

These authors contributed equally to this work. Molecular mechanisms that maintain lineage integrity of helper T cells are largely unknown. Here we show histone deacetylases (HDAC) 1 and 2 as crucial regulators of this process. Loss of HDAC1 and HDAC2 during late T cell development led to the appearance of MHC class II-Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#term