ORIGINAL ARTICLE Harmonizing FDG PET quantification while maintaining optimal

Purpose Point-spread function (PSF) or PSF + time-of-flight (TOF) reconstruction may improve lesion detection in onco-logic PET, but can alter quantitation resulting in variable stan-dardized uptake values (SUVs) between different PET sys-tems. This study aims to validate a proprietary software tool (EQ.PET) to harmonize SUVs across different PET systems independent of the reconstruction algorithm used. Methods NEMA NU2 phantom data were used to calculate the appropriate filter for each PSF or PSF+TOF reconstruction from three different PET systems, in order to obtain EANM compliant recovery coefficients. PET data from 517 oncology patients were reconstructed with a PSF or PSF+TOF recon-struction for optimal tumour detection and an ordered subset expectation maximization (OSEM3D) reconstruction know