Add to ORKGABSTRACT: Introduction: In this study we tested the hypothesis that tirasemtiv, a selective fast skeletal muscle troponin activator that sensitizes the sarcomere to calcium, could amplify the response of muscle to neuromuscular input in humans. Methods: Healthy men received tirasemtiv and placebo in a randomized
Background: Nemaline myopathy (NM), the most common non-dystrophic congenital myopathy, is character...
This phase 2, double-blind, placebo-controlled, hypothesis-generating study evaluated the effects of...
Bone is a biomechanical tissue shaped by forces from muscles and gravitation. Simultaneous bone and ...
Introduction: In this study we tested the hypothesis that tirasemtiv, a selective fast skeletal musc...
The identification of new targets for specific and effective therapies poses new challenges for the ...
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neu...
The identification and optimization of the first activators of fast skeletal muscle are reported. Co...
International audienceNemaline myopathy, a disease of the actin-based thin filament, is one of the m...
RATIONALE: Acquired diaphragm muscle weakness is a key feature in several chronic conditions, includ...
Rationale: Acquired diaphragm muscle weakness is a key feature in several chronic conditions, includ...
Objective: To investigate the potential of an acute bout of transcranial magnetic stimulation to ind...
Skeletal muscle is a convenient model system for studying basic questions on the neural regulation o...
Heart failure–mediated skeletal myopathy, which is character-ized by muscle atrophy and muscle metab...
PURPOSE: The effects of β(2)-agonists on human skeletal muscle contractile properties, particularly ...
Objective: Myotonia is caused by involuntary firing of skeletal muscle action potentials and causes ...
Background: Nemaline myopathy (NM), the most common non-dystrophic congenital myopathy, is character...
This phase 2, double-blind, placebo-controlled, hypothesis-generating study evaluated the effects of...
Bone is a biomechanical tissue shaped by forces from muscles and gravitation. Simultaneous bone and ...
Introduction: In this study we tested the hypothesis that tirasemtiv, a selective fast skeletal musc...
The identification of new targets for specific and effective therapies poses new challenges for the ...
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neu...
The identification and optimization of the first activators of fast skeletal muscle are reported. Co...
International audienceNemaline myopathy, a disease of the actin-based thin filament, is one of the m...
RATIONALE: Acquired diaphragm muscle weakness is a key feature in several chronic conditions, includ...
Rationale: Acquired diaphragm muscle weakness is a key feature in several chronic conditions, includ...
Objective: To investigate the potential of an acute bout of transcranial magnetic stimulation to ind...
Skeletal muscle is a convenient model system for studying basic questions on the neural regulation o...
Heart failure–mediated skeletal myopathy, which is character-ized by muscle atrophy and muscle metab...
PURPOSE: The effects of β(2)-agonists on human skeletal muscle contractile properties, particularly ...
Objective: Myotonia is caused by involuntary firing of skeletal muscle action potentials and causes ...
Background: Nemaline myopathy (NM), the most common non-dystrophic congenital myopathy, is character...
This phase 2, double-blind, placebo-controlled, hypothesis-generating study evaluated the effects of...
Bone is a biomechanical tissue shaped by forces from muscles and gravitation. Simultaneous bone and ...