Experimental Crystal data

R factor = 0.036; wR factor = 0.098; data-to-parameter ratio = 14.6. The asymmetric unit of the title compound, C21H22N4O4S, contains two molecules (A and B), in which the thiazine rings adopt an S-envelope conformation with the S atoms displaced by 0.621 (2) and 0.697 (2) A ̊ from the mean planes formed by the remaining ring atoms. The dihedral angles between the N-methylacetamide groups and the methoxybenzene rings are 8.67 (10) and 54.49 (6) in the two molecules and the equivalent torsion angles in the N-methylacetamide chains connecting the ring systems also differ. In the crystal, N— H O hydrogen bonds connect the components into C(4) [100] chains of alternating A and B molecules. The packing is consolidated by weak C—H O interactions, which generate a three-dimensional network. Related literature For therapeutic applications of benzothiazines, see: Turck et al. (1996); Lombardino et al. (1973); Zinnes et al. (1973). For therapeutic applications of pyrrazoles, see: Silverstein et al. (2000). For the properties and crystal structures of related pyrazolobenzothiazine derivatives, see: Ahmad et al. (2010a,b