Add to ORKGThe role of telomeres and telomerase as a target for cancer therapeutics is an area of continuing interest. This review is intended to provide an update on the field, pointing to areas in which our knowledge remains deficient and exploring the details of the most promising areas being advanced into clinical trials. Topics that will be covered include the role of dysfunctional telomeres in cellular aging and how replicative senescence provides an initial barrier to the emergence of immortalized cells, a hallmark of cancer. As an important transla-tional theme, this review will consider possibilities for selectively targeting telomeres and telomerase to enhance cancer therapy. The role of telomerase as an immunotherapy, as a gene therapy appr...
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolyti...
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolyti...
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolyti...
The past 25 years have seen unparalleled advances in our understanding of the molecular basis of can...
Abstract Cancer is an aging-related disease, while aging plays an important role in the development ...
Many of the fundamental molecular mechanisms underlying tumor biology remain elusive and, thus, deve...
Many of the fundamental molecular mechanisms underlying tumor biology remain elusive and, thus, deve...
Cancer is a leading cause of death worldwide, with approximately 18.1 million new cases and 9.6 mill...
The limited capacity to divide is one of the major differences between normal somatic cells and canc...
The limited capacity to divide is one of the major differences between normal somatic cells and canc...
The limited capacity to divide is one of the major differences between normal somatic cells and canc...
One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally ...
One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally ...
One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally ...
Rapid advances in our understanding of the molecular basis of cancer development and progression ove...
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolyti...
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolyti...
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolyti...
The past 25 years have seen unparalleled advances in our understanding of the molecular basis of can...
Abstract Cancer is an aging-related disease, while aging plays an important role in the development ...
Many of the fundamental molecular mechanisms underlying tumor biology remain elusive and, thus, deve...
Many of the fundamental molecular mechanisms underlying tumor biology remain elusive and, thus, deve...
Cancer is a leading cause of death worldwide, with approximately 18.1 million new cases and 9.6 mill...
The limited capacity to divide is one of the major differences between normal somatic cells and canc...
The limited capacity to divide is one of the major differences between normal somatic cells and canc...
The limited capacity to divide is one of the major differences between normal somatic cells and canc...
One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally ...
One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally ...
One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally ...
Rapid advances in our understanding of the molecular basis of cancer development and progression ove...
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolyti...
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolyti...
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolyti...