Hepatitis B Virus Single Nucleotide Polymorphism

Implication for health policy/practice/research/medical education: Chronic hepatitis B infection depends on many host and viral factors. One of the most important factors that had been concluded in many chronic infections including TB and other diseases was polymorphism among INF-γ receptor. Our current study was fo-cused on studying the polymorphisms in the γ interferon receptor among chronic HBV infected patients. Our findings demon-strated that there is an acceptable correlation between polymorphism in two regions of the receptor and the outcome of HBV infection to chronicity. Background: chronic hepatitis B virus (HBV) infection is a multifactorial disease that can result in serious clinical complications. Host genetic background especially the genes that encode immunologic factors like INF-γ and its receptor (IFN-γ R) are critical in the pathogenesis of infection. Objectives: The current study aimed to investigate the association between two single nucleotide polymorphisms (SNPs) at positions-611 and-56 within the promoter region of gamma interferon receptor1 gene (IFN-γ R1) and chronic HBV infection. Materials and Methods: Genomic DNA from peripheral blood samples of 200 chroni