RESEARCH ARTICLE Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in

Antibodies named TcCRA “Trypanosoma cruzi Cross Reactive Antibodies ” were detected in 47 % of blood donors from French population unexposed to the parasite. In order to evalu-ate the passive or active transmissibility of TcCRA and further characterize its role and etiol-ogy, we have conducted a study in a cohort of 47 patients who underwent allogeneic Hematopoietic Stem Cell Transplantations (allo-HSCT). Donors and recipients were tested for TcCRA prior to transplantation. Recipients were further tested during follow-up after transplantation. Demographical, clinical and biological data were collected. Our primary end-point was to assess the risk of TcCRA acquisition after transplantation. During this ini-tial analysis, we observed no seroconversion in patients receiving cells from TcCRA nega-tive donors (n = 23) but detected seroconversion in 4 out of 24 patients who received hematopoietic stem cells from positive donors. Here, we are discussing possible scenarios to explain TcCRA-immune status in recipient after transplantation