RESEARCH ARTICLE The balance between two a-J

f t LEF-1 has no transcriptional activation potential by it- Wnt signals to regulate the downstream genes [5,6]. Wang et al. BMC Gastroenterology 2012, 12:53 http://www.biomedcentral.com/1471-230X/12/53mote cell proliferation and inhibit differentiation throughof Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi Province, P. R. China Full list of author information is available at the end of the articleself, but it can act as an architectural transcription factor in the assembly of multiprotein enhancer complexes, to-gether with other lymphoid-specific proteins. For ex-ample, LEF-1, combined with ALY and other enhancer LEF-1 belongs to the multiple promoter gene family, which is usually aberrantly and differentially active in dis-ease. Multiple promoter genes are often characterized by the furthest 5- promoter producing a full-length polypep-tide with activities that differ significantly from those encoded by a second downstream promoter that is located inside the gene [7]. The full-length LEF-1 (LEF-1-FL) iso-form, containing the β-catenin binding domain, can pro-* Correspondence