RESEARCH c

DOI 10.1186/s12951-015-0082-8with Paclitaxel (PTX) to inhibit tumor and ascites and prolong patient’s survival [9]. It has been shown that the University of New South Wales, Kogarah, NSW, Australia Full list of author information is available at the end of the articleAngiogenesis, the development of new capillaries from existing vasculature, plays a key role in the pathogenesis of metastases [1]. VEGF is important in tumor angiogenesis, growth and metastasis [2,3], especially in ovarian cancers and other solid tumors [4,5]. Substantial evidence suggests that VEGF promotes the formation of ascites and is present at a very high levels in ascites of patients with rent ovarian cancer are known to be affected by malignant ascites (accumulation of fluid containing cancer cells in the abdomen) and develop intraperitoneal metastases, thus leading to treatment failure. Current therapies that exist for treating ascites are salt restriction, diuretics, radioactive isotopes, paracentesis and shunt placement [7]. Recently, the anti-angiogenic agents, such as Bevacizumab and the VEGF trap, have been shown to be effective in the reduction of ascites [8]. VEGF trap had been combined * Correspondence