Research Article Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex CentroidMixture Design

Copyright © 2013 Ashwini R. Madgulkar et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. e aimwas to determine the release-modifying effect of carboxymethyl xyloglucan for oral drug delivery. Sustained release matrix tablets of tramadol HCl were prepared by wet granulation method using carboxymethyl xyloglucan as matrix forming polymer. HPMCK100Mwas used in a small amount to control the burst effect which is most commonly seen with natural hydrophilic poly-mers. A simplex centroid designwith three independent variables and two dependent variables was employed to systematically opti-mize drug release pro�le. Carboxymethyl xyloglucan