Antibody-mediated imaging of amyloid b (Ab) in Alzheimer’s disease (AD) offers a promising strategy to detect and monitor specific Ab species, such as oligomers, that have important pathological and therapeutic relevance. The major current limitation of antibodies as a diagnostic and imaging device is poor blood-brain-barrier permeability. A classical anti-Ab antibody, 6E10, is modified with 10 kDa polyethylene glycol (PEG) and a positron emitting isotope, Copper-64 (tK = 12.7 h), and intravenously delivered to the TgCRND8 mouse model of Alzheimer’s disease. Modification of 6E10 with PEG (6E10-PEG) increases accumulation of 6E10 in brain tissue in both TgCRND8 and wild type control animals. 6E10-PEG differentiates TgCRND8 animals from wild ...
Visualization of amyloid-ß (Aß) pathology with PET has become an important tool for making a specifi...
In vivo imaging and quantification of amyloid-b plaque (Ab) burden in small-animal models of Alzheim...
This study investigated the in vivo properties of two heavy chain antibody fragments (V(H)H), ni3A a...
Antibody-mediated imaging of amyloid β (Aβ) in Alzheimer's disease (AD) offers a promising strategy ...
Antibody-mediated imaging of amyloid β (Aβ) in Alzheimer's disease (AD) offers a promising strategy ...
<div><p>Antibody-mediated imaging of amyloid β (Aβ) in Alzheimer's disease (AD) offers a promising s...
Alzheimer’s disease is the most common form of dementia and is classified as a progressive neurodege...
Few quantitative diagnostic and monitoring, tools are available to clinicians treating patients with...
Owing to their specificity and high-affinity binding, monoclonal antibodies have potential as positr...
Amyloid PET imaging with [11C]PIB enabled detection of Aβ for the first time in vivo. However, [11C]...
This study investigated the in vivo properties of two heavy chain antibody fragments (VHH), ni3A and...
The main histopathological hallmarks of Alzheimer’s disease are extracellular amyloid-beta (Aβ) plaq...
Visualization of amyloid-beta (A beta) pathology with PET has become an important tool for making a ...
Current Alzheimer’s Disease (AD) research suggests that early stage biomarkers which instigate memor...
Alzheimer disease is the most common cause of dementia in the world. Despite intensive research effo...
Visualization of amyloid-ß (Aß) pathology with PET has become an important tool for making a specifi...
In vivo imaging and quantification of amyloid-b plaque (Ab) burden in small-animal models of Alzheim...
This study investigated the in vivo properties of two heavy chain antibody fragments (V(H)H), ni3A a...
Antibody-mediated imaging of amyloid β (Aβ) in Alzheimer's disease (AD) offers a promising strategy ...
Antibody-mediated imaging of amyloid β (Aβ) in Alzheimer's disease (AD) offers a promising strategy ...
<div><p>Antibody-mediated imaging of amyloid β (Aβ) in Alzheimer's disease (AD) offers a promising s...
Alzheimer’s disease is the most common form of dementia and is classified as a progressive neurodege...
Few quantitative diagnostic and monitoring, tools are available to clinicians treating patients with...
Owing to their specificity and high-affinity binding, monoclonal antibodies have potential as positr...
Amyloid PET imaging with [11C]PIB enabled detection of Aβ for the first time in vivo. However, [11C]...
This study investigated the in vivo properties of two heavy chain antibody fragments (VHH), ni3A and...
The main histopathological hallmarks of Alzheimer’s disease are extracellular amyloid-beta (Aβ) plaq...
Visualization of amyloid-beta (A beta) pathology with PET has become an important tool for making a ...
Current Alzheimer’s Disease (AD) research suggests that early stage biomarkers which instigate memor...
Alzheimer disease is the most common cause of dementia in the world. Despite intensive research effo...
Visualization of amyloid-ß (Aß) pathology with PET has become an important tool for making a specifi...
In vivo imaging and quantification of amyloid-b plaque (Ab) burden in small-animal models of Alzheim...
This study investigated the in vivo properties of two heavy chain antibody fragments (V(H)H), ni3A a...