Research Article Adipose-Derived Stem Cells Alleviate Radiation-Induced Muscular Fibrosis by Suppressing the Expression of TGF-

Copyright © 2016 Wei Sun et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We aim to investigate the effects of adipose-derived stem cells (ASCs) transplantation on irradiation-induced skeletal muscle fibrosis. Sixty-four rabbits were randomly divided into ASCs group and PBS group followed by irradiation at unilateral hip with a single dose of 80Gy. Nonirradiated side with normal skeletalmuscle served as normal control. Skeletalmuscle tissues were collected from eight rabbits in each group at 1 w, 4w, 8w, and 26w after irradiation. Migration of ASCs was observed in the peripheral tissues along the needle passage in the injured muscle. The proportion of the area of collagen fibers to the total area in sections of ASCs group was lower than those of PBS groups at 4w, 8w, and 26w after irradiation. Significant decrease was noted in the integrated optimal density of the transforming growth facto