RESEARCH ARTICLE Differential regulation of t a s

is available at the end of the articleKrüppel-like Factor 3 (KLF3/BKLF) belongs to the KLF family of transcription factors, of which there are 17 members with diverse biological roles in development and cellular differentiation [1,2]. KLFs are characterized by a highly homologous C-terminal DNA-binding domain, containing three C2H2 zinc fingers that direct binding to CACCC boxes and related GC-rich sequences in the con-trol regions of target genes [3]. KLF3 is predominantly a transcriptional repressor which recruits a co-repressor to facilitate silencing of its target genes [4]. KLF3 is broadly expressed and has been shown to have roles in several processes, including erythropoiesis [5,6], adipo-genesis [7,8], muscle cell differentiation [9], and B cell development [10,11]. The Klf3 gene is highly expressed in the red blood cell lineage due to the presence of an erythroid specific pro-moter, which is driven by a related KLF, Krüppel-like Factor 1 (KLF1) [12]. KLF1 is a master regulator of erythropoiesis, with functional roles in many facets of erythroid develop-ment, including red blood cell structure, heme biosynthesis and globin gene regulation [13,14]. Loss of KLF1 is em