Add to ORKGChromosome 3p21–22 harbors two clusters of chemokine receptor genes, several of which serve as major or minor coreceptors of HIV-1. Although the genetic association of CCR5 and CCR2 variants with HIV-1 pathogenesis is well known, the role of variation in other nearby chemokine receptor genes remain unresolved. We genotyped exonic single nucleotide polymorphisms (SNPs) in chemokine receptor genes: CCR3, CCRL2, and CXCR6 (at 3p21) and CCR8 and CX3CR1 (at 3p22), the majority of which were non-synonymous. The individual SNPs were tested for their effects on disease progression and outcomes in five treatment-naı̈ve HIV-1/AIDS natural history cohorts. In addition to the known CCR5 and CCR2 associations
Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to huma...
International audienceChemokines and their receptors are key factors in the onset and progression of...
CXCR6 is a chemokine receptor and the primary coreceptor in SIV infection. A single nucleotide polym...
Chromosome 3p21–22 harbors two clusters of chemokine receptor genes, several of which serve as major...
The critical role of chemokine receptors (CCR5 and CXCR4) in human immunodeficiency virus-type 1 (HI...
The chemokine receptor gene, CCR5, has become a central theme in studies of host genetic effects on ...
The pivotal discovery that two chemokine receptors, CCR5 and CXCR4, serve along with the T-cell rece...
The finding that in addition to CD4 molecule HIV-1 uses, CCR5 or CXCR4 receptors to enter target cel...
Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AID...
Chemokine receptors are a subclass of seven transmembrane Gprotein coupled receptors, a number of w...
Chemokines are small protein molecules associated with various physiological events precisely in imm...
CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL18 (DC-CK1/PARC/AMAC-1) are potent chemoattractants produced by...
uman immunodeficiency virus 1 (HIV-1) co-receptors are transmembrane G-coupled proteins belonging to...
Objectives: Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and...
Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to huma...
Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to huma...
International audienceChemokines and their receptors are key factors in the onset and progression of...
CXCR6 is a chemokine receptor and the primary coreceptor in SIV infection. A single nucleotide polym...
Chromosome 3p21–22 harbors two clusters of chemokine receptor genes, several of which serve as major...
The critical role of chemokine receptors (CCR5 and CXCR4) in human immunodeficiency virus-type 1 (HI...
The chemokine receptor gene, CCR5, has become a central theme in studies of host genetic effects on ...
The pivotal discovery that two chemokine receptors, CCR5 and CXCR4, serve along with the T-cell rece...
The finding that in addition to CD4 molecule HIV-1 uses, CCR5 or CXCR4 receptors to enter target cel...
Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AID...
Chemokine receptors are a subclass of seven transmembrane Gprotein coupled receptors, a number of w...
Chemokines are small protein molecules associated with various physiological events precisely in imm...
CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL18 (DC-CK1/PARC/AMAC-1) are potent chemoattractants produced by...
uman immunodeficiency virus 1 (HIV-1) co-receptors are transmembrane G-coupled proteins belonging to...
Objectives: Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and...
Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to huma...
Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to huma...
International audienceChemokines and their receptors are key factors in the onset and progression of...
CXCR6 is a chemokine receptor and the primary coreceptor in SIV infection. A single nucleotide polym...