POSTER PRESENTATION Open Access How slow K+ currents impact on spike generation mechanism?

Neuronal adaptation is the change in the responsiveness of a neuron over time, and may improve coding information from an environment. Adaptation originates from various factors, including single neurons, synapses, and network dynamics. Here we investigate adaptation in a responsive-ness of a neuron. When a neuron received prolonged sti-mulation, it initially responds with a high firing rate, and the firing rate decrease. This is called spike-frequency adaptation, which is observed in most pyramidal neurons in various animals. Spike-frequency adaptation is usually accounted for by slow K+ currents, for example, the M-type K+ current (IM) and the Ca 2+-activated K+ current (IAHP), and the conductance-based (Hodgkin−Huxley type) models including the slow K+ currents have suc