Glycated Hemoglobin and All-Cause and Cause-Specific Mortality in Singaporean Chinese Without Diagnosed Diabetes: The Singapore Chinese Health Study Diabetes Care 2014;37:3180–3187 | DOI: 10.2337/dc14-0390 OBJECTIVE

Glycated hemoglobin (HbA1c) is a robust biomarker of the preceding 2 to 3months average blood glucose level. The aim of this study was to examine the association between HbA1c and mortality in a cohort of Southeast Asians. RESEARCH DESIGN AND METHODS Analysis of 7,388men andwomen,mean age 62 years, from the Singapore Chinese Health Studywho provided a blood sample at the follow-up I visit (1999–2004) and reported no history of diabetes, previous adverse cardiovascular events, or can-cer. A total of 888 deaths were identified through 31 December 2011 via registry linkage. Participants represented a random study sample of potential control subjects for a nested case-control genome-wide association study of type 2 di-abetes in the population. Hazard ratios (HRs) for all-cause and cause-specific mortality by six categories of HbA1c were estimated with Cox regression models. RESULTS Relative to participantswith an HbA1c of 5.4–5.6 % (36–38mmol/mol), participants with HbA1c ‡6.5 % (‡48 mmol/mol) had an increased risk of all-cause, cardiovas